An exciting opportunity now exists for a Postdoctoral Researcher in Computational Systems Biology/ Bioinformatics in the Lynn EMBL Australia Group, at The South Australian Health and Medical Research Institute (SAHMRI), in Adelaide, Australia (https://www.sahmriresearch.org/). The successful candidate will have a PhD in bioinformatics /computational biology (or in a related discipline) and a clear track record in the field as evidenced by publications in international peer-reviewed journals. The ideal candidate will have demonstrated experience in at least some of the following areas: network/systems biology; Using statistical approaches to relate high-throughput genomics data to clinical phenotypes; next generation sequencing data analysis; metagenomics. The successful candidate will work as part of a team that includes both computational biologists and wet-lab scientists investigating the immune system and cancer from a systems biology perspective – knowledge of immunology/cancer biology would therefore be an advantage. Prior postdoctoral experience would also be an asset, but exceptional recent PhD graduates will also be considered. The ability to work as part of a team and to manage multiple different projects simultaneously is essential. An initial 2-year full-time contract is available, potentially renewable subject to performance and availability of funding.SAHMRI: is a $250 million state-of-the-art medical research facility with excellent core facilities and services, hosting >700 researchers. The institute is located in the new $3 billion+ Biomed city in the Adelaide central business district, close to all the amenities of the city. Adelaide boasts a Mediterranean climate, beautiful beaches and is within an hour’s drive of world-class wine regions including the Barossa Valley.

EMBL Australia: The European Molecular Biology Laboratory is Europe’s flagship for the life sciences. The Australian government joined EMBL as an Associate Member in 2008. EMBL Australia was subsequently created to maximise the benefits of Australia’s associate membership of EMBL. EMBL Australia Group Leader positions are prestigious positions which come with up to 9 years funding for the group to conduct long-term high-impact research. The Lynn Group is one of 20 research teams that are being established at institutes around Australia under the EMBL model.

Key Responsibilities

• Play a leading role in the AIR clinical study, a study which will employ a systems vaccinology approach incorporating metagenomic and metabolomic analysis of the microbiota, together with blood gene expression data, extensive profiling of immune cell populations using flow cytometry and rich serological data on antibody responses in infants in the first year of life to investigate how the gut microbiota in early life shapes the immune system.
• Collaborate on other systems biology projects in the cancer area including the PRIMES project, a €12 million European Commission funded project that is investigating how certain cancer-relevant networks are rewired in the presence of oncogenic mutations and how to target them.
• Implement and develop efficient pipelines for the analysis of a wide range genome-wide data and where necessary develop new custom bioinformatics methods and/or pipelines for projects in the group/theme.
• Implement statistical approaches to identify novel associations between genome-wide data, host immune responses and disease.
• Provide collaborative support to others in the group/theme with bioinformatics components of their projects.
• Lead the writing of high-impact publications relating to the projects.

Qualifications

• PhD in computational biology, bioinformatics, computer science, physics, statistics or other relevant discipline.
• Significant experience in computational biology/ bioinformatics , ideally at a postdoctoral level.

Essential Experience, Knowledge and Skills

• Advanced programming skills in several of the following: Java, Python, C++, Perl, R.
• Prior experience working in a high performance computing environment.
• Demonstrated experience in network/systems biology and particularly in the analysis, interpretation and visualisation of genome-wide omics data and associating that data to clinical phenotypes and outcomes.
• Must be highly collaborative, be a strong team player and be able to manage multiple ongoing projects.

Everything we do is underpinned by our core values and our institute is dedicated to grow a culture that pursues, enables and demands research excellence. We are proud of the work we do and work hard as a team to make a positive difference to the community. Our values of Excellence, innovation, courage, integrity and teamwork are what help us achieve our goals. If these are also your values and goals, apply today.

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